Epstein-barr virus immortalization and latency

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Epstein-Barr virus immortalization and latency.

Epstein-Barr virus infects human B lymphocytes. The interaction between the virus and these cells has been the subject of investigation for over three decades. Recent in vitro and in vivo studies, reviewed here, are revealing the mechanisms by which EBV induces and controls proliferation through the expression of six viral nuclear proteins and two plasma membrane proteins. This genetic program ...

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Epstein-Barr virus (EBV) confers upon normal lymphocytes derived from bone marrow the ability to proliferate indefinitely in a test tube. This process, called immortalization, is crucial to the pathogenesis of EBV infections. Inside the immortalized lymphocyte the EBV genome exists as a complete multicopy circular plasmid which is probably not integrated into the cell chromosome. Most of the vi...

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ژورنال

عنوان ژورنال: Frontiers in Bioscience

سال: 1999

ISSN: 1093-9946,1093-4715

DOI: 10.2741/a433